New quality productivity of 35 MT/month of commonly used Silylation reagent - N,O-Bis(trimethylsilyl)acetamide

Name: N,O-Bis(trimethylsilyl)acetamide

M.F: C8H21NOSi2

M.W: 203.43

CAS: 10416-59-8

Physical: Appearance is colorless to light yellow transparent liquid, soluble in most organic solvents, Density: 0.78 g/cm³ (20°C) ,Boiling point: 71–73°C (10 mmHg).

N,O-Bis(trimethylsilyl)acetamide (BSA, CAS 10416-59-8) is a highly effective silylation-protecting reagent and pharmaceutical synthesis intermediate. By silylating active groups such as hydroxyl and amino groups, it enhances reaction selectivity and suppresses side reactions, making it widely applicable in the synthesis of critical medications including antibiotics and lipid-lowering drugs. Examples include:

●　Non-cephalosporin drugs: Ezetimibe

●　Cephalosporins: Cefalexin, Cefaclor, and Cefoperazone

Particularly in the preparation of Ezetimibe, a key intermediate for cholesterol absorption inhibitors, selective activation of multiple hydroxyl groups in the molecule is required during specific synthesis stages. BSA preferentially silylates hydroxyl groups with less steric hindrance to construct a temporary protective layer, ensuring subsequent acylation or alkylation reactions occur precisely at designated sites. This selective protection strategy effectively avoids side reactions such as intramolecular cyclization, increasing the overall yield by approximately 40%.